Georgina Grenville was born 1 September 1975 Durban, Natal, South Africa.

At the age of 14 Grenville won the opening around of the South African 1990 Elite 'Look of the Year' contest. She modelled briefly in Milan, before moving to New York and signing with the Next agency. She also did campaigns for Versace, Christian Dior, Armani Exchange and One of the first models of Gucci by Tom Ford. Grenville has made cameo appearances in an episode of the British comedy Absolutely Fabulous and in the film 54. She was also featured in the 1998 Pirelli calendar. She has two tattoos, including one with the word 'Shangri-La' around her navel.

She has dated actor Steven Dorff and photographer Sante D'Orazio.