The Audi R8 sports car, launched in early 2007, is based on the Gallardo platform, and uses a 4.2 litre V8 in place of the Gallardo's V10 to avoid competing directly with the Gallardo.

For the 2008 model year, an onboard computer, iPod connectivity with USB, heated mirrors, Q-citura stitching that originally could only be found on the Nera model, and a beige soft-top on the Spyder, were added to the Gallardo.

Lamborghini Gallardo LP560-4 was revealed at the 2008 Geneva Auto Show. It is powered by a new 5.2L V10 with FSI direct injection, generating 552 hp (412 kW) and 398 ft·lbf (540 N·m) of torque. The engine is heavily based on the new Audi RS6 V10. Unlike the precedent engine, this engine no longer has split crankpins, so it is not even firing, but Lamborghini says that due to the stiffer crankshaft it has less vibrations than the previous engine. Also, a revised transmission and four wheel drive system as well as a 20 kg (44 lb) weight loss are expected. The 4 at the end of the name refers to the Gallardo's permanent four-wheel-drive system. It also incorporates a new front bumper heavily influenced by the Lamborghini Reventon. Pricing of the Gallardo LP560-4 will start at around US$222,000.

Manufacturer	Lamborghini
Parent company	Audi AG
Production	2003–present
6,801 built (2003-2007)
Assembly	Sant'Agata Bolognese, Italy
Predecessor	Lamborghini Jalpa
Class	Sports car
Body style(s)	2-door coupé
2-door spyder
Layout	Mid-engine, four-wheel drive
Engine(s)	5.0 L V10
Transmission(s)	6-speed manual
6-speed single clutch semi-automatic
Wheelbase	2560 mm (100.8 in)
Length	4300 mm (169.3 in)
Width	1900 mm (74.8 in)
Height	1165 mm (45.9 in)
1184 mm (46.6 in) (Spyder)
Curb weight	1569 kg (3459 lb)
Related	Audi R8
Designer	Luc Donckerwolke